Israel launched strikes across Iran on Monday, defying US President Donald Trump’s appeal to avoid retaliation after Tehran fired a barrage of missiles. The escalation shattered hopes for stability as the war marked its 100th day, undermining a fragile April 8 truce and complicating Washington’s efforts to broker peace.

Explosions were reported in Tehran and two other cities, with the Israeli military confirming attacks on targets in western and central Iran. The strikes followed Iran’s launch of 11 missiles on Sunday, all intercepted without casualties. Trump, seeking to restrain Prime Minister Benjamin Netanyahu, warned that “Israel had its strike and Iran had its strike. We don’t need another one,” according to journalist Barak Ravid.

Calls for calm also came from British Foreign Secretary Yvette Cooper, who urged diplomacy, stressing that renewed conflict “is in no one’s interest.”

Iran, meanwhile, insisted that any permanent settlement must address Israel’s campaign against Hezbollah in Lebanon. Tehran’s Revolutionary Guards described their missile attack as a “warning” after Israel struck Beirut’s southern suburbs, killing two and wounding 20. Iran also targeted Kurdish groups in northern Iraq, accusing them of ties to Western and Israeli interests, while Israel intercepted a missile launched from Yemen.

The confrontation has rippled across the region, prompting airspace closures in Iran, Iraq, and Syria, and driving up crude oil prices amid fears over the Strait of Hormuz. Ordinary Iranians voiced despair at the uncertainty, with one resident saying daily life had become “a joke” as prices soared.

Diplomatic efforts continue, with Pakistan’s interior minister delivering messages from Islamabad to Tehran. Yet negotiations remain stalled, as Iran demands the release of $24 billion in frozen assets while Trump insists no funds will be unfrozen until an agreement is reached.